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In this study, we do not know to what extent, if at all, the TP would have been converted to E 2 in the neonatal treatment periods, and this will require further investigation. Tohoku Journal of Experimental Medicine. Exposure to TP during the first 25 days of life additionally led to a significant increase in both immature and adult body weight through an as yet unknown mechanism. The role of steroids in follicular growth. Matings were timed and presence of a vaginal plug designated embryonic day 0. International Journal of Molecular Medicine.

Introduction

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Androgens have been shown to play important roles in ovarian function not only acting as substrates for oestradiol E 2 production in preovulatory follicles but also by modulating ovarian function both directly and indirectly. Ultrasound in polycystic ovary syndrome — the measuring of ovarian stroma and relationship with circulating androgens: Premature ovarian failure in androgen receptor-deficient mice. Unless otherwise states, a two-tailed unpaired Student's t -test was used to evaluate the differences between rodent treatment groups in all other circumstances. Prenatal and neonatal androgen exposure interact to affect sexual differentiation in female rats. Effects of androgens on the development of mouse follicles growing in vitro. Foetal TP has no discernable effects upon the female rat Foetal TP did not affect folliculogenesis or fertility in immature or adult animals, as evidenced by the presence of normal numbers of CL in the adult animals, and normal follicle numbers and proportions at both ages.

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Briefly, for foetal TP treatment, pregnant dams were injected s. Steroids used include testosterone Beloosesky et al. To avoid foetal mortality that can be brought about by dystocia Welsh et al. Role of androgens in follicle maturation and atresia. Gynecologic and Obstetric Investigation. This is an Open Access article distributed under the terms of the Society for Reproduction and Fertility's Re-use Licence which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
A layer of flat squamous GCs indicated a primordial follicle. As outlined in the Introduction section, androgens can have profound positive and negative effects on ovarian follicle development as well as providing the essential substrate for E 2 production by preovulatory follicles. Steroids used include testosterone Beloosesky et al. Critical androgen-sensitive periods of rat penis and clitoris development. Mouse ovarian germ cell cysts undergo programmed breakdown to form primordial follicles. In Graphpad Prism, a P value for a Fisher transformation was then calculated to test for the significant differences between two sets of overlapping correlative data. Animals had access to water and a soy-free breeding diet made available ad libitum SDS; Dundee, Scotland.

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